Lovastatin
HMG-CoA reductase inhibitor / Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase (Ki=1nM for acid form).1,2 Induces apoptosis in various cell lines.3 Causes cell cycle arrest in early G1 phase.4 Clinically useful antihyperlipemic agent.5 Cell permeable
Biochemicals & reagents
75330-75-5
Mevinolin
1) Alberts et al. (1988), Discovery, biochemistry and biology of lovastatin; Am. J. Cardiol., 62 10J 2) Hancock et al. (1989), All ras proteins are polyisoprenylated but only some are palmitoylated; Cell, 57 1167 3) Park et al. (1999), Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis; Anticancer Res., 19 3133 4) Vilimanovich et al. (2015), Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells; Eur. J. Pharmacol., 765 415 5) Tobert et al. (1988), Efficacy and long-term adverse effect pattern of lovastatin; Am. J. Cardiol., 62 28J
-20°C
TARGET: HMG-CoA reductase -- PATHWAY: Cell cycle; Cholesterol metabolism; Fatty acid metabolism; Apoptosis inducer -- RESEARCH AREA: Cell death -- DISEASE AREA: Atherosclerosis; Heart disease