CL-316243
β3-adrenergic agonist / antiobesity / Potent and selective β-3 adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and decreases blood insulin and glucose levels1. Induces functionally active mitochondrial uncoupling protein (UCP) in white fat2. Active in vivo.
Biochemicals & reagents
151126-84-0
1) Yoshida et al. (1994), Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific beta 3-adrenoceptor agonist in yellow KK mice; Life Sci., 54 491 2) Yoshida et al. (1998),beta 3-Adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers; Am. J. Physiol., 274 E469
-20°C
TARGET: GPCR -- PATHWAY: Mitochondrial function; Carbohydrate metabolism -- RESEARCH AREA: Oxidative stress -- DISEASE AREA: Obesity; Diabetes