Oleoylethanolamide
GPR119 agonist: stimulates lipolysis / Endogenous anandamide-like lipid acting as a PPARα agonist but does not bind to cannabinoid receptors.1 Biosynthesis via the action of NAPE-PLD on N-acylphosphatidylethanolamine.2 Agonist at GPR1193 and has been suggested to be its endogenous ligand4. Inhibits food intake in rodents.5 Extends the lifespan of C. elegans.6
Biochemicals & reagents
111-58-0
OEA; Oleylethanolamide
1) Lo Verme et al. (2005), Regulation of food intake by oleoylethanolamide; Cell Mol.Life Sci. 62 708 2) Magotti et al. (2015), Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids; Structure 23 598 3) Overton et al. (2006), Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecules hypophagic agents; Cell Metab. 3 167 4) Brown (2007), Novel cannabinoid receptors; Br.J.Pharmacol. 152 567 5) Nielson et al. (2004), Food intake is inhibited by oral oleoylethanolamide; J.Lipid Res. 45 1027 6) Folick et al. (2015), Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans; Science 347 83
-20°C
TARGET: GPCR -- PATHWAY: PPAR; Fatty acid metabolism -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Obesity; Diabetes