Ginkgolide B
PAF antagonist / Platelet-activating factor (PAF) receptor antagonist (Ki = 1.3 μM)1. Inhibits neutrophil degranulation and superoxide production in vitro1. Inhibits PAF-induced bronchoconstriction in a guinea pig model2. Displays neuroprotective effects in various models3,4. Protects against focal cerebral ischemia via inhibition of the mitochondrial apoptotic pathway5.
Biochemicals & reagents
15291-77-7
BN 52021
1) Foldes-Filep et al. (1987), Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes; Biochem. Biophys. Res. Commun., 148 1412 2) Desquand et al. (1986), Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig; Eur. J. Pharmacol., 127 83 3) Maclennan et al. (2002), The CNS effects of Ginko biloba extracts and ginkgolide B; Prog. Neurobiol., 67 235 4) Li et al. (2013), Neuroprotective effect of ginkogolide B on bupivacaine-induced apoptosis in SH-SY5Y cells; Oxid. Med. Cell. Longev., 2013 159864 5) Wang et al. (2014), Neuroprotection against permanent focal cerebral ischemia by ginkgolides A and B is associated with obstruction of the mitochondrial apoptotic pathway via inhibition of c-Jun N-terminal kinase in rats; J. Neurosci. Res., 92 232
-20°C
TARGET: GPCR -- PATHWAY: Coagulation; Apoptosis inhibitor -- RESEARCH AREA: Neuroscience; Cell death; Oxidative stress -- DISEASE AREA: Ischemia; Kidney diseaseInflammation