PD 123319 ditrifluoroacetate
Angiotensin II type II antagonist / Potent (IC50 = 34 nM) and selective non-peptide angiotensin II type 2 (AT2) antagonist.1 Ameliorated symptoms of 2,4-dinitrobenzenesulfonic-induced colitis in rats via inhibition of NF-kB activation.2 PD123319 displayed protective effects in ischemia-reperfusion injury and oxidative damage in rat hearts.3
Biochemicals & reagents
136676-91-0
1) Blankley et al. (1991), Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype; J. Med. Chem. 34 3248 2) Zizzo et al. (2020); PD123319, angiotensin II type II receptor antagonist, inhibits oxidative stress and inflammation in 2,4-dinitrobenzene sulfonic acid-induced colitis in rat and ameliorates colonic contractility; Inflammopharmacology 28 187 3) Kilic et al. (2019); Angiotensin II type 2 receptor blocker PD123319 had more beneficial effects than losartan on ischemia-reperfusion injury and oxidative damage in isolated rat hearts; Can. J. Physiol. Pharmacol. 97 1124
-20°C
TARGET: GPCR -- PATHWAY: NFkappaB -- RESEARCH AREA: Oxidative stress -- DISEASE AREA: Ischemia; Inflammation