Jervine
Hedgehog pathway / Inhibitor of Hedgehog signaling (IC50 = 0.5-0.7 μM). Binds directly to Smoothened (Smo)1. Inhibits the response of target tissues to Sonic hedgehog signaling2. Induces COX-2 overexpression in human erythroleukemia cells3.
Biochemicals & reagents
469-59-0
11-Ketocyclopamine
1) Cooper et al. (1998), Teratogen-mediated inhibition of target tissue response to Shh signaling; Science, 280 1603 2) Mistretta et al. (2003), Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium; Dev. Biol., 254 1 3) Ghezale et al. (2013), Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect; Exp. Cell Res., 319 1043
-20°C
TARGET: GPCR -- PATHWAY: Hedgehog -- DISEASE AREA: Inflammation