SCH-202676
G-protein inhibitor / SCH-202676 is a reversible inhibitor of both agonist and antagonist binding to G protein-coupled receptors (GPCRs).1 IC50’s = 0.1-1.7 µM for nine GPCRs.1 Modification of GPCRs is accomplished via sulfhydryl modification.2,3
Biochemicals & reagents
265980-25-4
1) Fawzi et al. (2001) SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. Mol.Pharmacol. 59 30. / 2) Lewandowicz et al. (2006) The ‘allosteric modulator’ SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms Br.J.Pharmacol. 147 422 / 3) Goblyos et al. (2005) Synthesis and biological evaluation of a new series of 2,3,5-substituted[1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action J.Med.Chem. 48 1145
RT
TARGET: GPCR -- PATHWAY: cAMP / cGMP signaling -- RESEARCH AREA: Neuroscience; Immunology -- DISEASE AREA: Inflammation