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Naloxone HCl

Supplier:
Catalogue number:
10-2442-01
Size:
100 mg
Product is available in:
  • USA
  • Canada
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Opioid receptor antagonist / Naloxone (357-08-4) is a pan-opioid receptor antagonist, Ki=3.7, 9.2 and 33 nM for m, k and d opioid receptors respectively1. In clinical use in opiate abuse and overdose rescue.2 Blocks opiate- promoted wound healing.3 Attenuates the pruritic response to rimonabant in a rat model.4.

Product Type:

Biochemicals & reagents

CAS Number:

357-08-4

Reference:

1) Le Bourdonnec et al., (2008), Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opiod receptor antagonists with improved opiod receptor selectivity profiles: Bioorg. Med. Chem. Lett.. 18 2006 2) Boyer et al. (2012), Management of opioid analgesic overdose; New Engl. J. Med. 367 146 3) Wang et al. (2017), Opioids and opioid receptors orchestrate wound repair; Transl. Res. 185 13 4) Wright and Rodgers (2013), Low dose naloxone attenuates the pruritic but not anorectic response to rimonabant in male rats; Psychopharmacology (Berl.) 226 415

Storage Temperature:

-20°C

Additional Information:

TARGET: GPCR -- PATHWAY: cAMP / cGMP signaling -- RESEARCH AREA: Neuroscience; Wound healing -- DISEASE AREA: Addiction