www.mayflowerbio.com
Sales & Support: 314-485-5210

*

Kifunensine

Supplier:
Catalogue number:
10-2860-02
Size:
5 mg
Product is available in:
  • USA
  • Canada
$310.00 Shipping is calculated in checkout

Mannosidase inhibitor / Historically isolated from Kitasatosporia kifunensee.1 Inhibitor of class I α-mannosidases which inhibit glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.2 Inhibition of endoplasmic reticulum α-mannosidase I activity rescues the human α-sarcoglycan R77C mutation suggesting a new pharmacological approach for limb girdle muscular dystrophy type 2D patients carrying mutations that impair α-sarcoglycan trafficking.3 Improves maturation of misfolded proteins.4

Product Type:

Biochemicals & reagents

CAS Number:

109944-15-2

Alternative Names:

FR-900494

Reference:

1) Iwami et al. (1987), A new immunomodulator, FR-900494: taxonomy, fermentation, isolation, and physico-chemical and biological characteristics; J.Antibiot. (Tokyo) 40 612 2) Elbein et al. (1990), Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I; J.Biol.Chem. 265 15599 3) Bartoli et al. (2008), Mannosidase I inhibition rescues the human alpha-sarcoglycan R77C recurrent mutation; Hum.Mol.Genet. 17 1214 4) Wang et al. (2011), Inhibition of endoplasmic reticulum-associated degradation rescues native folding in loss of function protein misfolding diseases; J.Biol.Chem. 286 43454

Storage Temperature:

-20°C

Additional Information:

TARGET: Glycosylation -- PATHWAY: Degradation; Intracellular transport; Posttranslational modification; Carbohydrate metabolism