Milbemectin
RDL GABA agonist; Glutamate-gated Cl channel activator / An allosteric agonist at the Drosophila RDL GABA receptor.1,2 Also acts as an agonist at glutamate-gated chloride channels in insects.3 Mutations (specifically a G326E substitution) in the glutamate-gated chloride channel 3 (GluCl3) in phytophagous mites abolishes agonist activity resulting in resistance.4 Commercially used as an acaricide.
Biochemicals & reagents
1799297-76-9
1 Nakao et al. (2015), Comparison between the modes of action of novel meta-diamide and macrocyclic lactone insecticides on the RDL GABA receptor; Pestic. Biochem. Physiol., 120 101 2 Casida and Durkin (2015), Novel GABA receptor pesticide targets; Pestic. Biochem. Physiol., 121 22 3 Wolstenholme and Rogers (2005), Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics; Parasitology, 131 Suppl. S85 4 Mermans et al. (2017), A G326E substitution in the glutamate-gated chloride channel 3 (GluCl3) of the two-spotted spider mite Tetranychus urticae abolishes the agnostic activity of macrocyclic lactones; Pest. Manag. Sci. 73 2413
-20°C
TARGET: GABAA receptor -- PATHWAY: Ion channels -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Parasites