Flumazenil
Benzodiazepine antagonist / A benzodiazepine antagonist1, panspecific for α1,α,α orα5-containing GABAA receptors2. Reduces withdrawal sequelae in benzodiazepine dependence.3 Reverses the toxic effects, including coma and respiratory depression of zolpidem intoxication4 and gabapentin-induced coma5.
Biochemicals & reagents
78755-81-4
Ro 1722; Ro 15-1788
1) Möhler et al. (1981), Benzodiazepine antagonist Ro 15-1788; binding characteristics and interaction with drug-induced changes in dopamine turnover and cerebellar cGMP levels; J. Neurochem., 37 714 2) Doble et al. (1999), New insights into the mechanism of action of hypnotics; J. Psychophamrcol., 13(4 Suppl. 1) S11 3) Hood et al. (2014), Benzodiazepine dependence and its treatment with low dose flumazenil; Br. J. Clin. Pharmacol., 77 285 4) Lheureux et al. (1990), Zolpidem intoxication mimicking narcotic overdose: response to flumazenil; Hum. Exp. Toxicol., 9 105 5) Masciullo et al. (2021), Flumazenil therapy for a gabapentin-induced coma: a case report; J. Med. Case Rep., 15 242
-20°C
TARGET: GABAA receptor -- PATHWAY: Ion channels -- RESEARCH AREA: Neuroscience; Vesicles -- DISEASE AREA: Mood disorders