Cisplatin
Anticancer agent / Induces intra- and interstrand DNA adducts which poison topoisomerase I.1 Synergizes with topoisomerase I inhibitors such as topotecan.1 Induces apoptosis by sequential activation of caspase-8, -3 and -6 in osteosarcoma cells.2 Inhibits expression of X-linked inhibitor of apoptosis protein (XIAP) in human LNCaP cells.3 Numerous mechanisms inhibit propagation of cisplatin-induced DNA damage to signal apoptosis resulting in resistance.4 Clinically useful anticancer agent.
Biochemicals & reagents
15663-27-1
CDDP; cis-Diamineplatinum(II) dichloride
1) Van Waardenburg et al. (2004), Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin; J. Biol. Chem,, 279 54502 2) Siddik et al. (2003), Cisplatin: mode of cytotoxic action and molecular basis of resistance; Oncogene, 22 7265 3) Seki et al. (2000), Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma; Cancer Chemother. Pharmacol., 45 199 4) Nomura et al. (2004), Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells; Urol. Oncol., 22 453 5) Raghavan et al. (2015), Dimethylsulfoxide inactivates the anticancer effect of cisplatin against myelogenous leukemia cell lines in in vitro assays.; Indian J. Phamracol., 47 322
RT
TARGET: DNA -- PATHWAY: DNA damage; Apoptosis inducer; Cytotoxicity -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer