Monastrol
Kinesin Eg5 and mitosis inhibitor / Potent, cell-permeable, small molecule inhibitor of mitosis. Monastrol-arrested cells are characterized by monopolar spindles.1 Does not affect other motor proteins or tubulin. Specifically inhibits the mitotic molecular motor kinesin Eg5, a motor protein required for spindle formation (IC50 = 14 μM).2 Mimics the effect of amyloid β on long term potentiation in a cellular model of learning and memory.3 Enhances regeneration of adult axons.4
Biochemicals & reagents
254753-54-3
1) Mayer et al. (1999), Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen; Science, 286 971 2) Kapoor et al. (2000), Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of mitotic kinesin, Eg5; J. Cell Biol., 150 975 3) Ari et al. (2014), Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or reansmitter receptor function; Neurobiol. Aging, 35 1839 4) Lin et al. (2011), Inhibition of Kinesin-5, a microtubule-based motor protein, as a strategy for enhancing regeneration of adult axons; Traffic, 12 269
-20°C
TARGET: Cytoskeleton -- PATHWAY: Cell cycle -- RESEARCH AREA: Neuroscience