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Liproxstatin-1

Supplier:
Catalogue number:
10-4670-01
Size:
5 mg
Product is available in:
  • USA
  • Canada
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Ferroptosis inhibitor / Liproxstatin-1 is an inhibitor of ferroptosis (IC50 = 22 nM).1 It was able to mitigate tissue injury in a mouse model of hepatic ischemia/reperfusion injury.1 It protected mouse myocardium against ischemia/reperfusion injury via a decrease in VDAC1 and restoration of GPX4 levels.2 Liproxstatin-1’s mechanism of activity has been attributed to its activity as a radical-trapping antioxidant.3

Product Type:

Biochemicals & reagents

CAS Number:

950455-15-9

Reference:

1) Angeli et al. (2014), Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice; Nat. Chem. Biol. 16 1180 2) Feng et al. (2019), Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels; Biochem. Biophys. Res. Commun. 520 606 3) Zilka et al. (2017), On the mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death; ACS Cent. Sci. 3 232

Storage Temperature:

-20°C

Additional Information:

TARGET: Antioxidant -- PATHWAY: Ferroptosis; Lipid signaling; Redox -- RESEARCH AREA: Cell death; Oxidative stress -- DISEASE AREA: Ischemia