ST-034307
Adenylate cyclase 1 inhibitor, analgesic activity / A novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation.1 Displays analgesic properties in a mouse model of inflammatory pain.1
Biochemicals & reagents
133406-29-8
1) Brust et al. (2017), Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties; Sci. Signal., 10 eaah5381
RT
TARGET: Adenylyl cyclase -- PATHWAY: cAMP / cGMP signaling -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Pain; Addiction