IWP-2
Porcn inhibitor: Wnt/b-catenin pathway inhibitor / IWP-2 is an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC50=27nM) by inhibition of the O-acyltransferase Porcn1. Induces cardiomyocyte differentiation from human pluripotent stem cells2. An important tool to probe the involvement of the Wnt pathway in physiological processes3,4. Cell permeable.
Biochemicals & reagents
686770-61-6
1) Chen et al. (2009), Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer; Nature Chem. Biol., 5 100 2) Lian et al. (2012), Robust Cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling; Proc. Natl. Acad. Sci. USA, 109 1848 3) ten Berge et al. (2011), Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells; Nature Cell. Biol., 13 1070 4) Uyama et al. (2013), Wasf2: a novel target of intermittent parathyroid hormonr administration; Int. J. Mol. Med., 31 1243
-20°C
TARGET: Acyltransferase -- PATHWAY: Wnt -- RESEARCH AREA: Stem cells