NVS-STG2
Supplier:
Catalogue number:
10-4134-02
Size:
25 mg
Product is available in:
Molecular glue STING agonist / NVS-STG2 is a STING agonist that activates human STING by binding in a pocket between the transmembrane domains of neighboring STING dimers in a molecular glue-like manner (AC50 = 5.2 µM). Inactive with mouse STING. NVS-STG2 slowed tumor growth significantly in MC38 tumors inoculated into hSTING knock-in mice.
Product Type:
Biochemicals & reagents
CAS Number:
3030588-01-0
Reference:
1) Li et al. (2024), Activation of human STING by a molecular glue-like compound; Nat.Chem. Biol. 20 365
Storage Temperature:
-20°C
Additional Information:
TARGET: Molecular glue; STING -- PATHWAY: Cytokine -- RESEARCH AREA: Immunology -- DISEASE AREA: Cancer