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Tianeptine sodium salt

Supplier:
Catalogue number:
10-2937-02
Size:
50 mg
Product is available in:
  • USA
  • Canada
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Neuroprotective agent / Selective enhancer of serotonin uptake in the brain with no effect on noradrenalin or dopamine uptake.1 Clinically useful antidepressant.2 Displays neuroprotective effects against hypoxia in cell culture and against the deleterious effects of cytokines in vivo.3 Induces mTORC1 activation in rat hippocampal neurons and increases dendritic outgrowth, spine density and synaptic proteins.4 Attenuates LPS-evoked inflammatory activation of microglial cells in culture.5

Product Type:

Biochemicals & reagents

CAS Number:

30123-17-2

Reference:

1) Mennini et al. (1987), Tianeptine, a selective enhancer of serotonin uptake in rat brain; Naunyn-Schmied. Arch. Pharmacol., 336 478 2) Kato and Weitsch (1988), Neurochemical profile of tianeptine, a new antidepressant drug; Clin. Neuropharmacol., 11 S43 3) Plaisant et al. (2003), Neuroprotective properties of tianeptine: interactions with cytokines; Neuropharmacology, 44 801 4) Seo et al. (2016), Tianeptine induces mTORC1 activation in rat hippocampal neurons under toxic conditions; Psychopharmacology (Berl.), 233 2617 5) Slusarczyk et al. (2017), Anti-inflammatory properties of tianeptine on lipopolysaccharide-induced changes in microglial cells involve toll-like receptor-related pathways; J. Neurochem., 136 958

Storage Temperature:

RT

Additional Information:

TARGET: Monoamine transporter; Serotonin -- RESEARCH AREA: Oxidative stress; Neuroscience -- DISEASE AREA: Inflammation; Mood disorders