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ω-agatoxin IVA

Catalogue number:
11AGA001-00100
Size:
0.1 mg
Product is available in:
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ω-agatoxin IVA is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calcium channel (Cav2.1). It has been reported that ω-agatoxin IVA is a potent blocker of voltage-gated calcium channels in insect and vertebrate central neurons. The binding site for ω-agatoxin IVA has been localized in part to the extracellular S3–S4 loop in repeat IV of the α-1A Ca2+ channels, which is proximal to the S4 sensor domain. This is coherent with its functional effect (no pore-blocking activity, but gating modifier by a shift of channel activation towards more depolarized potentials). This makes this toxin a voltage-dependent blocker of P/Q calcium channels.

Product Type:

Peptides & proteins

CAS Number:

145017-83-0

Alternative Names:

ω-aga IVA, omega agatoxin IVA

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