life science research products, biological research products, biotechnology
Use * as wildcard:
iclines
RNAStorm
Pluripro

Kaliotoxin-1

Kaliotoxin-1
print page
Size: 0.1 mg
$219.00
Add to basket
Catalogue number:
08KTX002-00100
Name:
Kaliotoxin-1
Supplier:
Availability:

Kaliotoxin-1 has been isolated from the venom of the Scorpion Androctonus mauretanicus mauretanicus. Kaliotoxin-1 is a potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). This toxin also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Kaliotoxin-1 induces a transient period of fast flickering in the channel openings, followed by an almost complete blockage of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than that of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules.

Product Type:
Peptides & proteins
Storage Temp:
RT
Molecular Weight:
4150.37 Da
Reference:
Crest, M., et al. (1992) J Biol Chem; Fernandez, I., et al. (1994) Biochemistry