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Apamin

Catalogue number:
08APA001-00500
Size:
0.5 mg
Product is available in:
  • USA
  • Canada
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Apamin is a neurotoxin that was originally isolated from Apis mellifera. Apamin binds to and inhibits the SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord. It inhibits three subtypes of SK channels (SK1, SK2, and SK3) with different affinity. Apamin most likely acts as a pore blocker, although residues both inside and outside of the pore region of the SK channels participate in apamin binding. The SK channels are present in a wide range of excitable and non-excitable cells, including cells in the central nervous system, intestinal myocytes, endothelial cells, and hepatocytes.

Product Type:

Peptides & proteins

CAS Number:

24345-16-2

Reference:

Haux P, et al. (1967) Physiol Chem; Pease JH. et al. (1988).Biochemistry; Castle NA. et al. (1989) Trends Neurosci

Limit of Detection:

2027.34 Da

Storage Temperature:

RT