life science research products, biological research products, biotechnology
Use * as wildcard:
iclines
RNAStorm
Pluripro

Tertiapin Q

Tertiapin Q
print page
Size: 0.5 mg
$365.00
Add to basket
Catalogue number:
08TER001-00500
Name:
Tertiapin Q
Supplier:
Availability:

Tertiapin has been isolated from the venom of the Honeybee Apis mellifera. Tertiapin-Q is a mutant of tertiapin where M13 has been mutated by Q in order to increase your stability. This is a neurotoxin with presynaptic activity that blocks the inwardly rectifying Kir1.1 (KCNJ1) and Kir3.1/3.4 (KCNJ3/KCNJ5) potassium channels with high affinity by binding to the M1-M2 linker region of these channels in a 1:1 stoichiometry. Tertiapin-Q also inhibits calcium-activated large conductance BK-type (KCNMA/KCNMB) potassium channels in a concentration, and voltage-dependent manner, in addition to inhibiting Kir3.1/3.2 (KCNJ3/KCNJ6) heteromultimer potassiumchannels.

Product Type:
Peptides & proteins
CAS Number:
252198-49-5
Storage Temp:
RT
Molecular Weight:
2453.39 Da
Reference:
Kanjhan, R., et al. (2005) J Pharmacol Exp Ther; Jin, W., and Lu, Z. (1999) Biochemistry; Jin,W., et al. (1999) Biochemistry