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ω-conotoxin GVIA

ω-conotoxin GVIA
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Size: 1.0 mg
$554.00
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Catalogue number:
08CON003-01000
Name:
ω-conotoxin GVIA
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ω-conotoxin GVIA has been isolated from the venom of the cone Conus geographus. Omega-conotoxin GVIA acts at presynaptic membranes. It binds and blocks specifically Cav2.2 channel with an ED50 of 68pM.

Product Type:
Peptides & proteins
CAS Number:
106375-28-4
Storage Temp:
RT
Molecular Weight:
3036.05 Da
Reference:
Lew, M. J.,et al. (1997) Structure-function relationships of omega-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues, J Biol Chem; Sevilla, P., et al. (1993) Three-dimensional structure of omega-conotoxin GVIA determined by 1H NMR, Biochem Biophys Res Commun; Nishiuchi, Y., et al. (1986) Synthesis and secondary-structure determination of omega-conotoxin GVIA: a 27-peptide with three intramolecular disulfide bonds, Biopolymers; Olivera, B. M.,et al. (1984) Purification and sequence of a presynaptic peptide toxin from Conus geographus venom, Biochemistry; Seiji Ichida,et al. (2005) Characteristics of Omega-conotoxin GVI A and MVIIC Binding to Cav 2.1 and Cav 2.2 Channels Captured by Anti-Ca2+ Channel Peptide Antibodies, Neurochemical Research