Sigma-1 antagonist (Selective and potent). Sigma 1 receptor agonist (SARS-CoV-2 Nsp6 protein interacts with the Sigma receptor).
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- Applications:Was in clinical trials for other indication(s)
Biochemicals & reagents
1) Matsuno et al. (1996), Binding properties of SA4503, a novel and selective sigma 1 receptor agonist; Eur. J. Pharmacol. 306 271 2) Matsuno et al. (1997), SA4503, a novel cognition enhancer with sigma 1 agonistic properties; Behav. Brain Res. 83 221 3) Niitsu et al. (2012), Sigma-1 receptor agonists as therapeutic drugs for cognitive impairment in neuropsychiatric diseases; Curr. Pharm. Des. 18 875 4) Skuza and Rogoz et al. (2002), A potential antidepressant activity of SA4503, a selective sigma 1 receptor agonist; Behav.Pharmacol. 13 537 5) Lucas et al. (2008), Further evidence for an antidepressant potential of the selective sigma1 agonist SA4503: electrophysiological, morphological and behavioral studies; Int. J.Neuropsychopharmacol. 11 485 6) Mori et al. (2014), Inhibitory effects of SA4503 on the rewarding effects of abused drugs; Addict. Biol. 19 362 7) Nakazawa et al. (1998), Activation of sigma1 receptor subtype leads to neuroprotection in the rat primary neuronal cultures; Neurochem. Int. 32 337 8) Ruscher et al. (2011), The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke; Brain 134(Pt.3) 732 9) Ruscher et al. (2012), Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride on inflammation after stroke; PLoS One. 7 e45118 10) Yamashita et al. (2015), Neuroprotective effects of cutamesine, a ligand of the sigma-1 receptor chaperone, against noise-induced hearing loss; Int. J.Neurosci. Res. 93 788
SA4503 is a potent and selective sigma 1 agonist with σ1 IC50 = 17.4 nM and σ2 IC50 = 1784 nM (1). This compound has been investigated as a cognition enhancer (2,3), an antidepressant (4,5), as an anti-addiction agent (6), and as a neuroprotectant (7-10).