Sigma receptor agonist (high affinity). Sigma receptor agonist (SARS-CoV-2 Nsp6 protein interacts with the Sigma receptor).
- Datasheet: view or download
- Applications:Tool compound
Product Type:
Biochemicals & reagents
CAS Number:
97-39-2
Range:
1) Weber et al. (1986), 1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs; Proc.Natl.Acad.Sci.USA, 83 8784 2) Scherz et al. (1990), Synthesis and Structure-Activity Relationships of N,N’-Di-o-tolylguanidine Analogues, High-Affinity Ligands for the Haloperidol-Sensitive σ Receptor; J.Med.Chem., 33 2421
Limit of Detection:
239.32
Storage Temperature:
Room Temperature
Additional Information:
DTG is an agonist of the sigma (σ) receptor (1) with roughly equal potency against both subtypes (σ1 and σ2 IC50’s ~ 30nM) (2).