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GRL-0496

Supplier:
Catalogue number:
10-4960-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
$290.00 Shipping is calculated in checkout

Protease inhibitor: SARS-CoV chymotrypsin-like protease (3CLpro, Mpro, Nsp5). Inhibits key SARS-CoV protease (Nsp5) that has 99% similarity overall to that of SARS-CoV-2. Ghosh et al. Bioorg Med Chem Lett., 18:5684–5688 2008, https://doi.org/10.1016/j.bmcl.2008.08.082; Gordon et al. Nature, Apr 30 2020, https://doi.org/10.1038/s41586-020-2286-9.

Product Type:

Biochemicals & reagents

CAS Number:

1087243-14-8

Range:

1) Ghosh et al. (2008), Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors; Bioorg. Med. Chem.Lett, 18 5684

Limit of Detection:

272.69

Storage Temperature:

-20°C (des.)

Additional Information:

GRL-0496 is a potent inhibitor (IC50 = 30 nM in cell culture assays) of severe acute respiratory syndrome-coronavirus chymotrypsin-like protease (SARS-CoV 3CLpro) (1).