GRL-0496
Supplier:
Catalogue number:
10-4960-01
Size:
5 mg
Product is available in:
Protease inhibitor: SARS-CoV chymotrypsin-like protease (3CLpro, Mpro, Nsp5). Inhibits key SARS-CoV protease (Nsp5) that has 99% similarity overall to that of SARS-CoV-2. Ghosh et al. Bioorg Med Chem Lett., 18:5684–5688 2008, https://doi.org/10.1016/j.bmcl.2008.08.082; Gordon et al. Nature, Apr 30 2020, https://doi.org/10.1038/s41586-020-2286-9.
- Datasheet: view or download
- Applications:Tool compound
Product Type:
Biochemicals & reagents
CAS Number:
1087243-14-8
Range:
1) Ghosh et al. (2008), Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors; Bioorg. Med. Chem.Lett, 18 5684
Limit of Detection:
272.69
Storage Temperature:
-20°C (des.)
Additional Information:
GRL-0496 is a potent inhibitor (IC50 = 30 nM in cell culture assays) of severe acute respiratory syndrome-coronavirus chymotrypsin-like protease (SARS-CoV 3CLpro) (1).