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Boceprevir

Supplier:
Catalogue number:
10-5087-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
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Protease inhibitor: HCV NS3 protease. Inhibits key SARS-CoV-2 protease, Mpro (3CLpro) in vitro, and SARS-CoV-2 in cells. Ma et al. bioRxiv, May 8 2020, https://doi.org/10.1101/2020.04.20.051581.

  • Datasheet:   view or download
  • Applications:Approved drug (U.S.) that could be repurposed
Product Type:

Biochemicals & reagents

CAS Number:

394730-60-0

Range:

1.BA Malcom et al. Antimicrob. Agents Chemother. 2006 50:1013 2.C Ma et al. bioRxiv 2020 Preprint May 8, DOI: 10.1101/2020.04.20.051581

Limit of Detection:

519.7

Storage Temperature:

-20°C (des.)

Additional Information:

Boceprevir directly inhibits Hepatitis C virus (HCV) NS3 protease (overall binding constant for formation of covalent adduct, Ki* = 14 nM; initial inhibition constant Ki = 7.8 µM). This blocks NS3 autoactivation, and subsequent cleavage and maturation of other viral proteins necessary for replisome assembly. This reversible, slow-binding ketoamide also restores host interferon signaling obstructed by HCV, thus reactivating the immune response (1). Recently, this compound was also found to inhibit the key SARS-CoV-2 protease, Mpro (3CLpro) in vitro (Ki = 1.18 µM) and in cells (EC50 = 1.9 µM, virus-induced cytopathic effects (CPE) assay) (2).