Sales & Support: 314-485-5210


Ac-Leu-Leu-Methional (ALLM)

Catalogue number:
5 mg
Product is available in:
  • USA
  • Canada
$60.00 Shipping is calculated in checkout

Protease inhibitor: Calpain. Inhibits key SARS-CoV-2 protease, Mpro (3CLpro) in vitro, and SARS-CoV-2 in cells. Ma et al. bioRxiv, May 8 2020, https://doi.org/10.1101/2020.04.20.051581.

Product Type:

Biochemicals & reagents

CAS Number:



1) Sasaki et al. (1990), Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins J. Enzyme Inhib., 3 195 2) Vinitsky et al. (1992), Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex; Biochemistry, 31 9421

Limit of Detection:


Storage Temperature:


Additional Information:

Ac-Leu-Leu-Methional (ALLM) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki = 120 nM, calpain II, Ki = 230 nM) and other neutral cysteine proteases. This compound is a potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM) (1), a weak inhibitor of the chymotrypsin-like activity of the proteasome (2) and is cell permeable.