Biochemicals & reagents
1) Sasaki et al. (1990), Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins J. Enzyme Inhib., 3 195 2) Vinitsky et al. (1992), Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex; Biochemistry, 31 9421
Ac-Leu-Leu-Methional (ALLM) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki = 120 nM, calpain II, Ki = 230 nM) and other neutral cysteine proteases. This compound is a potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM) (1), a weak inhibitor of the chymotrypsin-like activity of the proteasome (2) and is cell permeable.