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Captopril

Supplier:
Catalogue number:
10-2253-02
Size:
5 g
Product is available in:
  • USA
  • Canada
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Protease inhibitor: ACE. Targets viral cell entry via inhibition of ACE2. Gordon et al. bioRxiv, Mar 23 2020, https://doi.org/10.1101/2020.03.22.002386.

  • Datasheet:   view or download
  • Applications:Approved drug (U.S.) that could be repurposed
Product Type:

Biochemicals & reagents

CAS Number:

62571-86-2

Range:

1) Cushman et al. (1999), Design of angiotensin converting enzyme inhibitors; Nat.Med. 5 1110 2) Orning et al. (1991), Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril; J.Biol.Chem. 266 16507

Limit of Detection:

217.28

Storage Temperature:

-20°C (des.)

Additional Information:

Captopril is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 = 0.022 μM (1) which also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and competitively (Ki = 6.0 μM for leukotriene B4 formation and Ki = 60 nM for L-lysine-p-nitroanilide) (2). This comound displays vasodilatory and antihypertensive effects in vivo and is a clinically useful antihypertensive agent.