Neuropilin-1 (NRP1) expression inhibitor; Acyl-CoA carboxylase inhibitor. NRP1 enhances SARS-CoV-2 infection of cells. TOFA blocks expression of NRP1, and Rotavirus replication, in cells. Cantuti-Castelvetri et al. bioRxiv, Jun 10 2020, https://doi.org/10.1101/2020.06.07.137802; Guseva et al. Cancer Biol. Ther., 12:80 2011, https://doi.org/10.4161/cbt.12.1.15721; Gaunt et al. J. Gen. Virol. 94:1310 2013, https://doi.org/10.1099/vir.0.050146-0.
Biochemicals & reagents
1) Halvorson et al. (1984), Inhibition of fatty acid synthesis in isolated adipocytes by 5-tetradecyloxy)-2-furoic acid; Lipids, 19 851 2) Guseva et al. (2011), TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status; Cancer Biol. Ther., 12 80 3) Zhou et al. (2003), Fatty acid synthesis inhibition triggers apoptosis during S phase in human cancer cells; Cancer Res., 63 7330 4) Schmidt et al. (1999), Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family; Mol. Cell. Endocrinol., 155 51 5) Ronnebaum et al. (2008), Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism; J. Biol. Chem., 283 14248
TOFA (RMI-14514) interferes with fatty acid synthase via inhibition of acetyl Co-A carboxylase (ACC1) (1), induces apoptosis in a variety of tumor cell lines (2,3) and stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells (4). This compound also impairs glucose-stimulated insulin secretion after chronic treatment (5).