TOFA (RMI-14514)

Neuropilin-1 (NRP1) expression inhibitor; Acyl-CoA carboxylase inhibitor. NRP1 enhances SARS-CoV-2 infection of cells. TOFA blocks expression of NRP1, and Rotavirus replication, in cells. Cantuti-Castelvetri et al. bioRxiv, Jun 10 2020, https://doi.org/10.1101/2020.06.07.137802; Guseva et al. Cancer Biol. Ther., 12:80 2011, https://doi.org/10.4161/cbt.12.1.15721; Gaunt et al. J. Gen. Virol. 94:1310 2013, https://doi.org/10.1099/vir.0.050146-0.