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INK-128

Supplier:
Catalogue number:
10-3362-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
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mTOR and PI3K inhibitor; Autophagy modulator. mTORC1 pathway members interact with SARS-CoV-2 N and Orf8 proteins. Gordon et al. bioRxiv, Mar 23 2020, https://doi.org/10.1101/2020.03.22.002386.

  • Datasheet:   view or download
  • Applications:In clinical trials for other indication(s)
Product Type:

Biochemicals & reagents

CAS Number:

1224844-38-5

Range:

1) Hsieh et al. (2012), The translational landscape of mTOR signaling steers cancer initiation and metastasis; Nature, 485 55 2) Gokmen-Polar et al. (2012) Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent oral antitumor activity in human breast cancer xenograft models; Breast Cancer Res. Treat., 136 673

Limit of Detection:

309.33

Storage Temperature:

-20°C (des.)

Additional Information:

INK-128 is a potent and selective, ATP-competitive inhibitor of mTOR kinase, Ki = 1.4 nM (1) and inhibits the growth and proliferation of various breast cancer cell lines and human endothelial cells (2).