INK-128
mTOR and PI3K inhibitor; Autophagy modulator. mTORC1 pathway members interact with SARS-CoV-2 N and Orf8 proteins. Gordon et al. bioRxiv, Mar 23 2020, https://doi.org/10.1101/2020.03.22.002386.
- Datasheet: view or download
- Applications:In clinical trials for other indication(s)
Biochemicals & reagents
1224844-38-5
1) Hsieh et al. (2012), The translational landscape of mTOR signaling steers cancer initiation and metastasis; Nature, 485 55 2) Gokmen-Polar et al. (2012) Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent oral antitumor activity in human breast cancer xenograft models; Breast Cancer Res. Treat., 136 673
309.33
-20°C (des.)
INK-128 is a potent and selective, ATP-competitive inhibitor of mTOR kinase, Ki = 1.4 nM (1) and inhibits the growth and proliferation of various breast cancer cell lines and human endothelial cells (2).