Biochemicals & reagents
1) Hsieh et al. (2012), The translational landscape of mTOR signaling steers cancer initiation and metastasis; Nature, 485 55 2) Gokmen-Polar et al. (2012) Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent oral antitumor activity in human breast cancer xenograft models; Breast Cancer Res. Treat., 136 673
INK-128 is a potent and selective, ATP-competitive inhibitor of mTOR kinase, Ki = 1.4 nM (1) and inhibits the growth and proliferation of various breast cancer cell lines and human endothelial cells (2).