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Catalogue number:
50 mg
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Methyltransferase (COMT) inhibitor. COMT (catechol O-methyltransferase) interacts with SARS-CoV-2 Nsp7. Gordon et al. bioRxiv, Mar 23 2020, https://doi.org/10.1101/2020.03.22.002386.

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  • Applications:Approved drug (U.S.) that could be repurposed
Product Type:

Biochemicals & reagents

CAS Number:



1) Forsberg et al. (2003), Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat; J. Pharmacol. Exp. Ther., 304 498 2) Merello et al. (1994), Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson’s disease; J. Neurol. Neurosurg. Psychiatry, 57 186 3) Giovanni et al. (2010), Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta amyloid and protect against amyloid-induced toxicity; J. Biol. Chem., 285 14941 4) Chen et al. (2016), Entacapone is an Antioxident More Potent than Vitamin C and Vitamin E for Scavenging of Hypochlorous Acid and Peroxynitrite, and the Inhibition of Oxidative Stress-induced Cell Death; Med. Sci. Monit., 22 687

Limit of Detection:


Storage Temperature:

-20°C (des.)

Additional Information:

Entacapone is a potent catechol O-methyltransferase (COMT) inhibitor with IC50 = 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively (1). This compound increases the bioavailability of L-DOPA as adjunct therapy for Parkinson's disease (2), inhibits α-synuclein aggregation in vitro and inhibits α-synuclein-induced cell death in PC-12 cells (3), is an antioxidant and also inhibits oxidative stress-induced cell death (4).