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H89 · 2HCl

Supplier:
Catalogue number:
10-2144-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
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Kinase inhibitor: PKA. PKA interacts with SARS-CoV-2 Nsp13. Gordon et al. bioRxiv, Mar 23 2020, https://doi.org/10.1101/2020.03.22.002386.

Product Type:

Biochemicals & reagents

CAS Number:

127243-85-0

Range:

1) Lochner and Moolman (2006), The many faces of H89: a review; Cardiovasc. Drugs, 24 261 2) Bain et al. (2007), The selectivity of protein kinase inhibitors: a further update; Biochem.J. 408(Pt3) 297

Limit of Detection:

519.28

Storage Temperature:

-20°C (des.)

Additional Information:

H-89 is a commonly used inhibitor of protein kinase A (PKA IC50 = 140 nM) which inhibits a variety of other kinases including S6K1 (IC50 = 80 nM), MSK1 (120 nM), ROCK II (270 nM), PKBα (2.6 µM), PKD, PRK2, RSK1 and 2, SGK, AMPK, CHK1 and MAPKAP-K1b (2.8 µM) (1,2).