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Ruxolitinib

Supplier:
Catalogue number:
10-4511-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
$150.00 Shipping is calculated in checkout

Kinase inhibitor: JAK. Inhibits MARK2/3, which interact with SARS-CoV-2 Orf9b. Gordon et al. bioRxiv, Mar 23 2020, https://doi.org/10.1101/2020.03.22.002386.

  • Datasheet:   view or download
  • Applications:"Cytokine storm" drug (approved, U.S.), in COVID-19 clinical trials
Product Type:

Biochemicals & reagents

CAS Number:

941678-49-5

Range:

1) Verstovsek et al. (2009), Therapeutic potential of JAK2 inhibitors; Hematology Am. Soc. Hematol. Educ. Program, 2009(1) 636 2) Quintas-Cardama et al. (2010), Preclinical characterization of the selective JAK1/2 inhibitor INCB01824: Therapeutic implications for the treatment of myeloproliferative neoplasms; Blood, 115 3109 3) Farr et al. (2017) Targeting cellular senescence prevents age-related bone loss in mice; Nat. Med., 23 1072 4) Li et al. (2017) Identification of a novel functional JAK1 S646P mutation in acute lymphoblastic leukemia; Oncotarget, 8 34687

Limit of Detection:

306.37

Storage Temperature:

-20°C

Additional Information:

Ruxolitinib is a potent and selective JAK1&2 inhibitor with IC50s=2.7, 4.5 and 322 nM for JAK1, JAK2 and JAK3 respectively (1). This compound blocks IL-6 signaling (IC50=281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50=127 nM) (2) and inhibits the proinflammatory secretome of senescent cells (3). The JAK1 S646P mutant is highly sensitive to ruxolitinib (4). It is a clinically relevant cancer chemotherapeutic.