Biochemicals & reagents
1) Pressman, (1976) Biological applications of ionophores; Annu.Rev.Biochem. 45 501 / 2) Furlong et al., (1998) Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification Cell Death Diff. 5 214 / 3) Inai et al. (1997) Valinomycin induces apoptosis of ascites hepatoma cells (AH-130) in relation to mitochondrial membrane potential; Cell Struc.Funct. 22 555
Valinomycin is a selective K+ ionophore capable of transporting potassium ions through lipid membranes (1) and it can induce apoptosis in cells by causing a rapid loss of mitochondrial membrane potential via potassium efflux (2,3).