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Valinomycin

Supplier:
Catalogue number:
10-2112-01
Size:
10 mg
Product is available in:
  • USA
  • Canada
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Ionophore; Autophagy modulator. Reduces replication of related coronavirus MERS-CoV via SKP2 inhibition. Gassen et al. Nat. Commun, 10:5770 2019, https://doi.org/10.1038/s41467-019-13659-4.

Product Type:

Biochemicals & reagents

CAS Number:

2001-95-8

Range:

1) Pressman, (1976) Biological applications of ionophores; Annu.Rev.Biochem. 45 501 / 2) Furlong et al., (1998) Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification Cell Death Diff. 5 214 / 3) Inai et al. (1997) Valinomycin induces apoptosis of ascites hepatoma cells (AH-130) in relation to mitochondrial membrane potential; Cell Struc.Funct. 22 555

Limit of Detection:

1111.35

Storage Temperature:

-20°C

Additional Information:

Valinomycin is a selective K+ ionophore capable of transporting potassium ions through lipid membranes (1) and it can induce apoptosis in cells by causing a rapid loss of mitochondrial membrane potential via potassium efflux (2,3).