Valinomycin
Ionophore; Autophagy modulator. Reduces replication of related coronavirus MERS-CoV via SKP2 inhibition. Gassen et al. Nat. Commun, 10:5770 2019, https://doi.org/10.1038/s41467-019-13659-4.
- Datasheet: view or download
- Applications:Tool compound
Biochemicals & reagents
2001-95-8
1) Pressman, (1976) Biological applications of ionophores; Annu.Rev.Biochem. 45 501 / 2) Furlong et al., (1998) Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification Cell Death Diff. 5 214 / 3) Inai et al. (1997) Valinomycin induces apoptosis of ascites hepatoma cells (AH-130) in relation to mitochondrial membrane potential; Cell Struc.Funct. 22 555
1111.35
-20°C
Valinomycin is a selective K+ ionophore capable of transporting potassium ions through lipid membranes (1) and it can induce apoptosis in cells by causing a rapid loss of mitochondrial membrane potential via potassium efflux (2,3).