A77 1726
Immunosuppressant; DHODH inhibitor. Inhibits Sars-CoV-2 in cells, possibly through UTP depletion. Xiong et al. bioRxiv, Mar 12 2020, https://doi.org/10.1101/2020.03.11.983056.
- Datasheet: view or download
- Applications:Approved drug (U.S.) that could be repurposed
Biochemicals & reagents
108605-62-5
1) Manna et al. (1999), Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression; J. Immunol., 162 2095 2) Davis et al. (1996), The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase; Biochemistry, 35 1270 3) Seah et al. (2008), Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726; Drug Metab. Lett., 2 153
270.21
-20°C
A77 1726 is a pyrimidine biosynthesis inhibitor and immunomodulator (1) which inhibits the mitochondrial dihydroorotate dehydrogenase (DHODH) (2). Leflunomide is rapidly metabolized in human hepatocytes to A77 1726 (3) and is also cell permeable.