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Mycophenolic acid

Supplier:
Catalogue number:
10-2087-01
Size:
100 mg
Product is available in:
  • USA
  • Canada
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Immunosuppressant. Inhibits IMPDH2, which interacts with SARS-CoV-2 Nsp14; Inhibits SARS-CoV-2 in cells. Gordon et al. bioRxiv, Mar 23 2020, https://doi.org/10.1101/2020.03.22.002386; Gordon et al. Nature, Apr 30 2020, https://doi.org/10.1038/s41586-020-2286-9.

  • Datasheet:   view or download
  • Applications:Approved drug (U.S.) that could be repurposed
Product Type:

Biochemicals & reagents

CAS Number:

24280-93-1

Range:

1) Eugui et al. (1991), Lymphocyte-selective cyostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depletion; Scand. J. Immunol., 33 161 2) Jonsson et al. (2002), Mycophenolic acid inhibits inosine 5’-monophosphate dehydrogenase and suppresses production of pro-inflammatory cytokines, nitric oxide and LDH in macrophages; Cell. Immunol., 216 93 3) Allison et al. (1993), Mechanisms of action of mycophenolic acid; Ann. NY Acad. Sci., 696 63 4) Quemeneur et al. (2002), Mycophenolic acid inhibits IL-2-dependent T cell proliferation, but not IL-2-dependent survival and sensitization to apoptosis; J. Immunol., 169 2747

Limit of Detection:

320.35

Storage Temperature:

Room Temperature

Additional Information:

Mycophenolic acid is an immunomodulator (1) which blocks the biosynthesis of guanine nucleotides via inhibition of inosine 5’-monophosphate dehydrogenase which suppresses the production of proinflammatory cytokines, nitric oxide and LDH in macrophages (2,3). It balso inhibits IL-2 -dependent T cell proliferation (4).