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Fingolimod (FTY-720)

Catalogue number:
250 mg
Product is available in:
  • USA
  • Canada
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Immunosuppresant; Sphingosine-1-phosphate receptor agonist. Limits 'cytokine storm'. Wan-Jin Chen, Phase II clinical trial "Efficacy of Fingolimod in the Treatment of New Coronavirus Pneumonia (COVID-19)" April 2020, https://clinicaltrials.gov/ct2/show/NCT04280588.

  • Datasheet:   view or download
  • Applications:"Cytokine storm" drug (approved, U.S.), in COVID-19 clinical trials
Product Type:

Biochemicals & reagents

CAS Number:



1) Brinkmann et al. (2002), The immune modulator FTY720 targets spingosine-1-phosphate receptors; J. Biol. Chem., 277 21453 2) Wolf et al. (2009), The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo; J. Immunol., 183 3751 3) Awojoodu et al. (2013), Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis; Proc. Natl. Acad. Sci. USA, 110 13785 4) Chiba (2005), FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors; Pharmacol. Ther., 108 308

Limit of Detection:


Storage Temperature:

-20°C (des.)

Additional Information:

Fingolimod (FTY-720) is an analog of sphingosine which, when taken up into cells, is phosphorylated and acts as an agonist at sphingosine-1-phosphate receptors (S1P1/3) (1). This compound potently inhibits regulatory T cell proliferation in vitro and in vivo (2), enhances microvascular remodeling via expansion of arterioles and capillary networks (3). It is also a potent immunomodulator (4).