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Immunomodulator; MTP and Calcineurin inhibitor. Blocks replication of SARS-CoV, and other coronaviruses, in cells. de Wilde et al. J Gen Virol., 92:2542-2548 2011, https://doi.org/10.1099/vir.0.034983-0; Guy et al. Science, 368 829-830 May 22 2020, https://doi.org/10.1126/science.abb9332; Laise et al. bioRxiv, May 17 2020, https://doi.org/10.1101/2020.05.12.091256.
- Datasheet: view or download
- Applications:Approved drug (U.S.) that could be repurposed with caution
Biochemicals & reagents
1) Liu et al. (1993), FK506 and ciclosporin: molecular probes for studying intracellular signal transduction ; Trends Pharmacol. Sci., 18 334
Limit of Detection:
Cyclosporine is an immunosupressant whereby the CsA-cyclophilin complex binds to and inhibits calcineurin, a type 2B phosphatase. This compound is also cell permeable.