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U-18666A

Supplier:
Catalogue number:
10-1075-02
Size:
50 mg
Product is available in:
  • USA
  • Canada
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Cholesterol transport inhibitor. Inhibits feline Coronavirus infection through cholesterol trafficking. Takano et al. Antiviral Res. 145:96-102, 2017, https://doi.org/10.1016/j.antiviral.2017.07.022.

Product Type:

Biochemicals & reagents

CAS Number:

3039-71-2

Range:

1) Sexton et al (1983) Effects of 3.beta.-[2-(diethylamino)ethoxy]androst-5-en-17-one on the synthesis of cholesterol and ubiquinone in rat intestinal epithelial cell cultures. Biochemistry 22 5687 / 2) Liscum and Faust (1989) The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one. J.Biol.Chem. 264 11796 / 3) Cenedella, (2009) Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes: Lipids 44, 477

Limit of Detection:

387.61 ∙ 36.46

Storage Temperature:

Room Temperature (des.)

Additional Information:

U18666A is an oxidosqualene reductase inhibitor (1) which inhibits the egress of cholesterol from late endosomes and lysosomes (2). This compound is also used to study Niemann-Pick disease and for assessing the importance of molecular trafficking through the lysosomal pathway in other conditions (3).