Biochemicals & reagents
1) Picaud et al. (2016), Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia; Sci.Adv. 2 e1600760 2) Pan et al. (2017), The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells; Oncotarget 8 94104
Bromosporine is a potent pan-Bromodomain (BRD) inhibitor (1) and it was able to reactivate HIV-1 replication in different latency models (2).