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Bromodomain inhibitor. SARS-CoV-2 transmembrane protein E binds to the bromodomain-containing proteins BRD2 and BRD4.
- Datasheet: view or download
- Applications:Tool compound
Biochemicals & reagents
1) Picaud et al. (2016), Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia; Sci.Adv. 2 e1600760 2) Pan et al. (2017), The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells; Oncotarget 8 94104
Limit of Detection:
Bromosporine is a potent pan-Bromodomain (BRD) inhibitor (1) and it was able to reactivate HIV-1 replication in different latency models (2).