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JQ1 (+/-)

Supplier:
Catalogue number:
10-1361-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
$260.00 Shipping is calculated in checkout

Bromodomain inhibitor. SARS-CoV-2 transmembrane protein E binds to the bromodomain-containing proteins BRD2 and BRD4. Gordon et al. bioRxiv, Mar 23 2020, https://doi.org/10.1101/2020.03.22.002386.

Product Type:

Biochemicals & reagents

CAS Number:

1268524-69-1

Range:

1) Filippakopoulos et al. (2010), Selective inhibition of BET bromodomains; Nature, 468 1067

Limit of Detection:

457

Storage Temperature:

Room Temperature

Additional Information:

JQ1 (+/-) is a potent BET bromodomain inhibitor with an IC50 = 17.7, 32.6, 76.9 and 12942 nM for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. The competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers (1).