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Umifenovir

Supplier:
Catalogue number:
10-4472-02
Size:
50 mg
Product is available in:
  • USA
  • Canada
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Antiviral agent. In clinical use for influenza; blocks viral fusion to cell. Tu et al. Int. J. Mol. Sci. 21:2657, Apr 10 2020.

  • Datasheet:   view or download
  • Applications:Approved drug (Russia); in COVID-19 clinical trials
Product Type:

Biochemicals & reagents

CAS Number:

131707-23-8

Range:

1) Blasing et al. (2014), Arbidol as a broad-spectrum antiviral: an update; Antiviral Res, 107 84 2) Boriskin et al. (2008) Arbidol: a broad-spectrum antiviral compound that blocks viral fusion; Curr. Meed. Chem., 15 997 3) Brooks et al. (2012) Antiviral activity of Arbidol, a broad-spectrum drug for use against respiratory viruses, varies according to test conditions; J. Med. Virol., 84 170 4) Leneva et al. (2009) Characteristics of Arbidol-resistant mutants of influenza virus: Implications for the mechanism of anti-influenza action of arbidol; Antiviral Res., 81 132 5) Wang et al. (2020) The anti-influenza drug, arbidol, is an efficient inhibitor of SARS-CoV-2 in vitro; Cell Discov., 6 28 6) Vankadari (2020) Arbidol: A Potential Antiviral Drug for the Treatment of SARS-CoV-2 by Blocking Trimerization of the Spike Glycoprotein; Int. J. Antimicrob. Agents, 105998

Limit of Detection:

513.9

Storage Temperature:

-20°C

Additional Information:

Umifenovir is a broad-spectrum antiviral medication (1). It has shown activity against influenza A, B,and C, respiratory syncytial, SARS-CoV, adeno, parainfluenza type 5, polio, rhino, coxsackie, hanta, chikungungya, hepatitis B and C viruses (2,3). This compound also blocks hemagglutinin-mediated membrane fusion of influenza virus particles (2) and has recently been shown to inhibit SARS-CoV2 infection by blocking virus entry as well as release from endolysosomes during intracellular trafficking (5). It has been suggested that Umifenovir may block trimerization of the spike glycoprotein, a key step in host cell adhesion (6).