Biochemicals & reagents
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Umifenovir is a broad-spectrum antiviral medication (1). It has shown activity against influenza A, B,and C, respiratory syncytial, SARS-CoV, adeno, parainfluenza type 5, polio, rhino, coxsackie, hanta, chikungungya, hepatitis B and C viruses (2,3). This compound also blocks hemagglutinin-mediated membrane fusion of influenza virus particles (2) and has recently been shown to inhibit SARS-CoV2 infection by blocking virus entry as well as release from endolysosomes during intracellular trafficking (5). It has been suggested that Umifenovir may block trimerization of the spike glycoprotein, a key step in host cell adhesion (6).