Emetine
Antiparasitic, Antiviral. Inhibits SARS-CoV-2 replication in cells. Choy et al. Antivir. Res., 178:104786, June 2020; https://doi.org/10.1016/j.antiviral.2020.104786.
- Datasheet: view or download
- Applications:Approved drug (U.S.); beginning COVID-19 clinical trials
Biochemicals & reagents
483-18-1
1) MR Lee J R Coll Physicians Edinb. 2008 38:355 2) Q Sun et al. Oncol. Rep. 2019 42:1735 3) S Yang et al. Cell Discov. 2018 4:31 4) K-T Choy et al. Antivir. Res. 2020 178:104786 5) E Cuyas et al. Cell Cycle 2015 14:3527
553.6
-20°C (des.)
Emetine is one of the active ingredients of ipecac root extract which is used as an emetic (1). This compound induces apoptosis in breast cancer cells via inhibition of Wnt/β-catenin signaling (2) and also inhibits the Zika and Ebola virus in vitro and in vivo, targeting viral entry and replication by inhibiting viral RNA polymerase and host lysosomal function (3). It also inhibits SARS-CoV-2 replication in cells (EC50 for viral load reduction is 0.46 M) (4) and is a useful agent for inhibiting protein synthesis in eukaryotic cells by virtue of its inhibition of the ribosome 40S subunit (5).