Chloroquine phosphate
Antimalarial; autophagy inhibitor; endosomal acidification fusion inhibitor. In clinical trials (alongside hydroxychloroquine) for SARS-CoV-2 infection; multiple potential mechanisms, including inhibiting viral endocytosis; attenuating the "cytokine storm"; binding Sigma 1 receptor (SARS-CoV-2 Nsp6 protein interacts with the Sigma receptor). Gordon et al. bioRxiv, Mar 23 2020, https://doi.org/10.1101/2020.03.22.002386; Hu et al. Nat. Nanotechnol., Mar 23 2020, https://doi.org/10.1038/s41565-020-0674-9; Wang et al. Cell Res 30:269–271, Feb 4 2020, https://doi.org/10.1038/s41422-020-0282-0.; Schrezenmeier & Dörner Nat. Rev. Rheumatol., 16:155-166, March 2020, https://doi.org/10.1038/s41584-020-0372-x; Guy et al. Science, 368 829-830 May 22 2020, https://doi.org/10.1126/science.abb9332.
Biochemicals & reagents
50-63-5